As far as I know there is no page in the web, where you find the really interesting speedup tricks.
Some (few) more or (mostly) less useful hints you find here: http://wiki.python.org/moin/PythonSpeed/PerformanceTips
The information given here can at least give some hints where to search for possible performance improvements.
But you shouldn't believe all the information given here. Some have never been true, some others are no longer right as those information refers to older Python versions.
Most of the TLE Python code I see in the forum e.g. gets TLE because of non-optimal implementation:
1. Avoid unnecessary calculations.
2. Use an appropriate data structure.
That will help in many cases. If there is much I/O that could be a problem, especially if type conversions are involved.
That's an interesting field and you can learn a lot by own experiments. Be creative!
